Primary Antibody Matched Pairs
Biotium Annexin A1 / (Hairy Cell Leukemia Marker)(6E4/3), CF740 conjugate, 0.1mg/mL
Annexin A1 belongs to the annexin family. It plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. In resting conditions Annexin A1 is localized to the cytoplasm. Upon activation it is mobilized to the membrane and secreted. Annexin A1 and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. Expression of the ANXA1 gene is upregulated in hairy cell leukemia (HCL). Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluo
Medchemexpress LLC CD70 Rat HEK293 F 100ug
CD70 is the ligand of CD27 in activated T and B lymphocytes is an important cytokine in CD70-CD27 pathway involving with the generation and maintenance of T cell immunity[1] CD70 is a surface antigen also shows antiviral activity and regulates viability of tumor cells and regulatory T cells[2][3] As for CD70 protein in rat contains TNF 2 domain (57-188 a a) and transmembrane helix belonging to the tumor necrosis factor (TNF) family CD70 Protein Rat (HEK293 Fc) is 150 amino acids in length (Q46-P195) and is expressed in the HEK293 cells with N terminal hFc-tag
Medchemexpress LLC S100A9 Human 250ug
Recombinant human S100A9 protein supplied as a lyophilized powder (250 μg). S100A9 is a calcium- and zinc-binding regulator involved in pro-inflammatory signaling, immune cell migration, and metal ion chelation; it forms a heterodimer with S100A8 and modulates NF-κB and STAT pathways. Intended for research use.
- Recombinant human protein with UniProt accession P06702.
- Purity greater than 95% by reducing SDS-PAGE.
- Expressed in E. coli and supplied tag free.
- Available in multiple unit sizes; supplied lyophilized for stability.
- Do not reconstitute below 100 μg/mL in ddH2O; aliquot and store frozen to avoid freeze-thaw.
Biotium GAD2 / GAD65 (GABAergic Neuronal Marker)(GAD2/2362), CF594 conjugate, 0.1mg/mL
This MAb recognizes a protein of 65 kDa, which is identified as glutamic acid decarboxylase 2 (GDA2). It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD's) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67). GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD's are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes
Sino Biological Recombinant Anti-BCMA Antibody, Rabbit Monoclonal 100 µL
This antibody was obtained from a rabbit immunized with purified, recombinant Human BCMA (rh BCMA; Catalog#10620-H08H; NP_001183.2; Met1-Ala54).
Revvity Health Sciences Inc IVISense 645 MAL Fluorescent Dye (1 mg) (VivoTag)
IVISense 645 MAL Fluorescent Dye (1 mg) (VivoTag)
ABclonal Technology TNFRSF13C Rabbit pAb
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Sino Biological Anti-RARS Antibody, Rabbit Polyclonal 100 µL
Produced in rabbits immunized with E. coli-derived Human RARS fragment, and purified by antigen affinity chromatography.
Cayman Chemical IP Wash BuFR DeTRgent10X 50mL
IP Wash Buffer Detergent (10X) has been tested and formulated to work exclusively with Cayman’s Protein A/G Coated Plate Immunoprecipitation Kit (Item No. 601970)
ABclonal Technology CCT6B Rabbit pAb
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants.
ABclonal Technology PDGFD Rabbit pAb
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.
AdipoGen IL-1alpha (mouse) Matched Pair Detection Set (1 Set)
Matched Pair Detection Set. Detects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 2000pg/ml. Sensitivity: 10pg/ml. IL-1alpha lacks a signal peptide and is secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.